Healthfacts - Antidepressant ineffective for kids - tricyclic antidepressants
Tricyclic antidepressant drugs appear to be no more effective than a placebo in the treatment of depression in children and adolescents, according to an analysis published last month in the British Medical Journal. This old-line family of antidepressants includes seven drugs sold under numerous brand names, such as Elavil and Norpramin.
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Earlier research had shown tricyclic antidepressants to be of equivocal benefit to young people. The new analysis pooled results from six studies comparing the effectiveness of tricyclic antidepressants with placebos in depressed children, aged six to 18 years. The investigators advise further research on the efficacy of the newer antidepressants, such as Prozac and Zoloft, in the treatment of depressed children. They also advise exploration of other strategies, such as family therapy and psychotherapy.
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